Publications by authors named "L G Tham"
The marine alkaloid erebusinone is a secondary metabolite isolated from the Antarctic sponge . Initial biological assays have shown that erebusinone increases amphipod mortality, probably by inhibition of the biosynthesis of molting hormone (ecdysone). Herein, we report the first total synthesis of the proposed structure of erebusinone and a structural revision.
View Article and Find Full Text PDFTwo novel pyrroloiminoquinone alkaloids, 6-chlorodamirone A and 6-bromodamirone A, have been identified for the first time from the marine sponge sp. (order: Poecilosclerida: family Latrunculiidae), sourced from Western Australia. Alongside these new compounds, seven previously known metabolites were also isolated.
View Article and Find Full Text PDFVolenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial.
Nephrol Dial Transplant
December 2024
Background: Volenrelaxin is a half-life-extended recombinant human relaxin protein developed for improving kidney perfusion and cardiorenal function. This study assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of volenrelaxin following single- and multiple-ascending doses (SAD and MAD) administration.
Methods: In this Phase 1, four-part, randomized, double-blinded, placebo-controlled SAD and MAD study in healthy participants, SAD participants (n = 56) received an intravenous or subcutaneous dose of volenrelaxin or placebo in a dose-ascending manner.
Article Synopsis
- The study focuses on the Boletaceae mushroom family, which includes porcini mushrooms, and aims to resolve their evolutionary relationships using extensive genomic data from 418 specimens.
- A comprehensive phylogenetic analysis provided strong statistical support for most branches of the family tree, identifying new subfamilies and estimating the family's origin in the early Cretaceous.
- The research highlights the complex history of Boletaceae, linking their dispersal and diversification to significant geological events, and lays the groundwork for future studies on their biogeography.
Introduction: Childhood injury is one of the leading causes of death globally, with falls being the sixth leading cause. This study aimed to examine the demographics, patterns of injury and temporal risk factors for falls from height above 3 m in Singapore.
Methods: This is a retrospective study conducted on patients who presented after a fall to a paediatric emergency department at a tertiary hospital between January 2011 and July 2017.