[The significance of the blood kinin system indices for the diagnosis of latent forms of rheumatism].

A study of the kinin and fibrinolytic systems of the blood in 280 rheumatic patients with isolated or prevailing stenosis revealed that latent forms of rheumatism were characterized by an increase of kininogenesis, reduction of kininase capacity of the blood and depression of fibrinolysis in the absence of acute-phase reactions which allows to use these data a supplementary informative test for the diagnosis of the latent course of rheumatism.

[Methodological features of teaching clinical pharmacology].

The paper is concerned with experience in teaching clinical pharmacology in the Donetsk Medical Institute. The authors discuss the appropriateness of teaching clinical pharmacology (CP) to fourth-year students, lectures in CP to fourth-, fifth- and sixth-year students in accordance with the study of the main clinical specialties (therapy, surgery, pediatrics, etc.), and introduction of a cycle of lectures and practical studies on CP in the curriculum of clinicians' postgraduate education.

[Optimization of the composition of the radioprotective complex APAETP+mexamine and analysis of its action].

The method of mathematical theory of experiment was used to find optimum variants of the radioprotective complex APAETP + mexamine. The character of their pharmacological interaction, depending on their dose ratio, was determined. It is suggested that it is conditioned by the specific role of different mechanisms involved in the radioprotective effect.

[Radioprotective effect of drug combinations on the small intestine].

The study of the radioprotective effect of complexes containing small amounts of cystamine or gammaphos mixed with mexamine, gutimine and ethyrone on mouse small intestine showed high efficiency of the drugs as determined by cellularity and DNA-synthesizing activity of intestinal epithelium. This is connected with the influence of the complex mexamine + gutimine + ethyrone on the pharmacodynamics and pharmacokinetics of cystamine and gammaphos.