[The effect of the synthetic analog of prostaglandin E2 sulprostone on the adenylate cyclase system in decidual tissue of women].

Activities of adenylate cyclase and phosphodiesterase were studied in decidual tissue of women, pregnancy of which was interrupted within the first term by means of synthetic analogue of prostaglandin E2 sulprostone; decidual tissue obtained after surgical abortion served as a control. Content of cAMP in decidual tissue was decreased 4-fold after administration of sulprostone. At the same time, activity od adenylate cyclase was decreased 2-3-fold, while activity of phosphodiesterase was unaltered.

[Prostaglandin and cAMP levels in the endometrium of women with a normal menstrual cycle].

The content of prostaglandins and cAMP was determined in the endometrium of healthy women with a regular menstrual cycle in its different phases. It was shown that the PGE2 level in the proliferative (the 7th-10th day of the cycle) and secretory (the 24th-26th day of the cycle) phases was the same. At the same time the level of PGE2 in the secretory phase of the cycle was 3 times higher than in the proliferative phase.

[Comparative effects of prostaglandins and ACTH on the production of corticosterone and cyclic AMP in isolated adrenal gland cells of rats].

The authors compared the effect of prostaglandin PGE2 and ACTH on corticosterone and cAMP production in isolated adrenal cells of rats. PGE2 stimulated steroidogenesis in the concentrations of 0.01-1.