Clinical, Analytical, and Echocardiographic Associations of Impaired Cardiorespiratory Fitness After Anthracycline Chemotherapy in Breast Cancer: EPIC Fitness Study.

Purpose: This study explores the effects of anthracycline chemotherapy (AC) on breast cancer patients, focusing on changes in body composition, advanced echocardiographic parameters at rest and during exercise, and biomarkers; and subsequently assesses whether these parameters are associated with impaired cardiorespiratory fitness (CRF).

Methods: In this prospective study, we evaluated women with early-stage breast cancer undergoing AC at three visits: before AC, 1 month after, and 6 months post-AC.

Results: The study included 32 women with breast cancer, with functional disability increasing from 9.

Synthetic Strategies for the Development of Novel Heterocycles as Larvicides Targeting Aedes aegypti Linn.

Background: Owing to their extensive utilization as pesticides, heterocycles assume a fundamental role in the management of vector-borne diseases. Despite the presence of numerous heterocyclic compounds in commercial insecticides and larvicides, resistance to pesticides still demands novel strategies to current pest control methods. Considering these facts, this review aims to survey the synthesis and SAR of heterocyclic molecules with larvicidal activity against Aedes aegypti Linn.

Sign Language Recognition System for Deaf Patients: Protocol for a Systematic Review.

Background: Individuals with hearing impairments may face hindrances in health care assistance, which may significantly impact the prognosis and the incidence of complications and iatrogenic events. Therefore, the development of automatic communication systems to assist the interaction between this population and health care workers is paramount.

Objective: This study aims to systematically review the evidence on communication systems using human-computer interaction techniques developed for deaf people who communicate through sign language that are already in use or proposed for use in health care contexts and have been tested with human users or videos of human users.

Actinomyces odontolyticus: A Rare Agent of Exit-Site Infection in Peritoneal Dialysis.

Exit-site infections (ESIs) of peritoneal dialysis catheters can cause serious complications if not promptly treated. Uncommon pathogens like are infrequently associated with these infections. We report a 26-year-old woman with end-stage renal disease due to Alport syndrome, presenting with recurrent purulent discharge and erythema at the Tenckhoff catheter exit site.

Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood.

Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach.

Case Description: Two cases of HMF in children are reported. The first case involves an eight-year-old boy with hypochromic macules on the trunk and root of the upper and lower limbs, while the second case is a six-year-old boy with widespread hypochromic patches.