[Possibility of inverse development of morphological changes in the rat myocardium provoked by large doses of dopamine].

It is shown that Wistar male rats keeping without medication and stressful effects for a month after administration of big doses of dopamine for two weeks does not lead to complete inverse development of heart remodeling. A decrease of the heart's mass occurs mainly because of a decrease of the right ventricle mass. The greatest changes of the extracellular matrix take place in the right ventricle: collagen level grows more noticeably, edema of the extracellular space relieves, correlations between collagen and blood vessels, cardiac hystiocytes and blood vessels increase aggravating right ventricular remodeling.

[The ecological-morphological aspects of adaptation and the role of the macrophages in body dehydration].

The morphological aspects of rearrangement of macrophages in white rats' subcutaneous areolar tissue during dehydration and their impact on the recovery of osmotic homeostasis were studied. A response of macrophages to dehydration with preliminary injection of antioxidant dibunol was revealed. Macrophages respond to dehydration by a rise in number, elevated cytoplasmic activity of lipolytic enzymes (beta-oxibutyrate dehydrogenase), and a peculiar ultrastructural rearrangement, i.

[Significance of biochemical indices of liver fibrosis].

Correlation between content of hydroxyproline in urine, protein-bound hydroxyproline, alpha 2-macroglobulin as well as of collagen peptidase activity in blood serum and the intensity of collagen accumulation in liver tissue were studied in experimental liver tissue cirrhosis, which developed after chronic intoxication of rats with CCl4. Distinct relationship was shown between the level of hydroxyprolinuria and amount of collagen in liver tissue. Content of protein-bound hydroxyproline, alpha 2-macroglobulin and the collagen peptidase activity were quite unaltered in blood serum during the cirrhosis development.