Publications by authors named "L G Perez-Blas"
Leishmaniases are a group of vector-borne zoonotic diseases of public health relevance within the tropical and subtropical regions of the world. The state of Yucatan is a vulnerable and receptive area to localized cutaneous leishmaniasis (LCL) due to its proximity to the high-transmission endemic states of Campeche and Quintana Roo. Autochthonous cases of LCL caused by () have been documented in the state, showing a geographical expansion of the disease.
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- Generation 4 polyamidoamine dendrimer (G4-PAMAM) has a unique globular structure that leads to various biological effects, including cytotoxicity due to its positive charges, which can be more pronounced in cancer cells with high negative charges.
- The study utilized advanced techniques like UHPLC-QTOF-MS/MS to analyze G4-PAMAM's chemical structure and understand its charge distribution.
- G4-PAMAM demonstrated significant antiproliferative effects on HMC-1 and K-562 cancer cell lines over 24, 48, and 72 hours, and was found to localize in the cytoplasm and nucleus of these cells.