Publications by authors named "L G Lutzker"
Article Synopsis
- Fine particulate matter (PM) exposure can lead to immune system issues through epigenetic changes, potentially impacting pregnancy outcomes.
- The study used advanced profiling techniques to link PM exposure with altered immune responses and specific histone modifications in immune cells of both pregnant and nonpregnant women.
- Findings suggest that high maternal PM exposure correlates with lower IL-27 levels in newborns and affects the inflammatory response in pregnant women, indicating possible pathways for complications during pregnancy.
Background: Evidence in the literature suggests that air pollution exposures experienced prenatally and early in life can be detrimental to normal lung development, however the specific timing of critical windows during development is not fully understood.
Objectives: We evaluated air pollution exposures during the prenatal and early-life period in association with lung function at ages 6-9, in an effort to identify potentially influential windows of exposure for lung development.
Methods: Our study population consisted of 222 children aged 6-9 from the Fresno-Clovis metro area in California with spirometry data collected between May 2015 and May 2017.
Background: Ambient air pollutant (AAP) exposure is associated with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. Previous studies have shown methylation of immune genes associate with exposure to air pollutants in pregnant women, but the cell-mediated response in the context of typical pregnancy cell alterations has not been investigated. Pregnancy causes attenuation in cell-mediated immunity with alterations in the Th1/Th2/Th17/Treg environment, contributing to maternal susceptibility.
View Article and Find Full Text PDFBackground: Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children.
Objective: This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children.
Methods: We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO), nitrogen oxides (NO), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM)) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)).