[Nervous system disorders in workers engaged into acrylonitrile production].

The article deals with results of clinical examination covering workers of acrylonitrile production on Krasnoyarsk synthetic rubber plant. The authors first described nervous system disorders in people having variable duration of exposure to acrylonitrile. Severity of these disorders was connected with the poison concentration in workplace, with content of inclusion complex containing acrylonitrile and hemoglobin in RBC of the exposed individuals.

[Schooling conditions and children's morbidity at schools of small towns of the Krasnoyarsk Territory].

The paper gives a brief analysis of the prevalence and trends of childhood morbidity in small towns of the Krasnoyarsk Territory. Morbidity in small towns is shown to be greater than the average territorial rate. The increase in overall morbidity in children is affected by the schooling environment where a child stay 6-8 hours daily and that ensures no conditions for keeping and promoting the child's health at school at the present stage.

[Biological monitoring of exposure to alkylating xenobiotics by determining them using a new analytical approach in complexes with hemoglobin, plasma proteins and mercapturic acids in urine. II. Acrylamide].

A new simple and prompt procedure for measuring acrylamide (propenamide, PA) in PA-derived mercapturic acid, such as N-acetyl-S-(2-propenamide)-L-cysteine (N-Ac-PAC), and in hemoglobin (Hb) and plasma protein adducts in the rats expose to PA was developed, by employing gas chromatography (GC). PA in mercapturic acids or proteins was liberated on high-temperature heating in an injector port during the working procedure of a GC capillary after preoxidation of sulfur atoms in PA-bound cysteine to a sulfoxide form with hydrogen peroxide and analyzed. This method resulted in 87% of PA in authentic N-Ac-PAC.

[Biological monitoring of exposure to alkylating xenobiotics by determining them in complexes with plasma proteins, hemoglobin, mercapturic acids from urine of rats and industrial workers. I. Acrylonitrile].

A parent molecule of acrylonitrile (cyanoethylene, CE) may be isolated from its the model compound S-(2-cyanoethylene)-1-cysteine, as well as from its N-acetyl derivative and hemoglobin (Hb) and plasma proteins from the intoxicated animals and workers engaged in manufacturing synthetic rubber made from acrylonitrile. The developed procedure consists in the 1.5% H2O2 oxidation of a CE adduct for 30 min, followed by addition of a sample into the gas chromatographic injector at 250 degrees C, resulting in the release of CE from the adducts and in the current ingress of carrier gas into the capillary column in order to separate and determine with a FTD detector.