Publications by authors named "L G Khachatryan"
Background: Early childhood caries (ECC) is a significant public health concern affecting children globally. Recent studies suggest a potential association between the presence of Candida albicans (C. albicans) in the oral cavity and the risk of ECC, but findings have been inconsistent.
View Article and Find Full Text PDFAim Of The Study: to determine the frequency of joint lesions (JnL) in children with juvenile localized scleroderma and it's possible correlation with autoantibodies and markers of fibrosis.
Materials And Methods: 500 children with JLS (370 girls and 130 boys) were studied retrospectively for the joint lesion, using standard physical examination, ultrasound examination (UlS) X-ray, MRI. In 190 patients we investigated antinuclear antibodies (antinuclear factor (ANF), rheumatoid factor (RF), antitopoisomerase 1 and anticentomere antibodies, antibodies to DNA, autoantibodies to collagen (Cab) types I-IV, cryoglobulins (CG), serum fibronectine (FN) and hyalyronic acid (HA) levels.
Objective: To investigate the spectrum of neurological disorders in children with juvenile localized scleroderma (JLS) on face and JLS without plaques on face and head.
Materials And Methods: 156 children with JLS were examined were with a neurological examination MRI, EEG, genetic thrombophilia markers detection.
Results: Neurological disorders (ND) were found in 56 from 114 (49%) of the patients with scleroderma of head and face (LSH)(group1) and in 30% (13 from 42) with JLS without plaques on face (Group 2).
Linear scleroderma of head and face (LSH) in children is a severe disorder, that results in hemiatrophy of skin, subcutaneuse tissue, bones with functional disabilities, neurologic disorders and uveal involvement. The aim of the research was to establish uveal involvement in children with hemifacial scleroderma. Materials and methods: A retrospective analysis was done in a group of 110 children with hemifacial scleroderma.
View Article and Find Full Text PDFArticle Synopsis
- The infant gut microbiota changes significantly during early life, which is crucial for developing the immune system, absorbing nutrients, and metabolic functions.
- Short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, produced by gut bacteria from dietary fibers, play vital roles in energy supply, immune regulation, and gut health.
- Disruptions in gut microbiota and SCFA production are linked to various pediatric health issues, highlighting the importance of understanding SCFAs for improving child health and developing targeted therapies.