Typing of HLA susceptibility alleles as complementary tool in diagnosis of controversial cases of pediatric celiac disease.

Objectives: Diagnosis of celiac disease (CeD), an immune-mediated disorder, is based on clinical presentation, a panel of serological markers, and the histopathological findings in duodenal biopsies. Commonly, pediatric CeD patients fulfill these criteria for diagnosis. However, lack of correlation between serology tests and histology, or no accessible biopsies because of clinical conditions or during the COVID pandemic, are conditions that led to inconclusive diagnoses.

Maintaining Local Adaptation Is Key for Evolutionary Rescue and Long-Term Persistence of Populations Experiencing Habitat Loss and a Changing Environment.

The Anthropocene is marked by increased population extirpations and redistributions driven primarily by human-induced climate change and habitat loss. Habitat loss affects populations by removing occupiable area, which reduces carrying capacity through a reduction in resources, and fragmenting the landscape, which can reduce gene flow with potential consequences for adaptation to changing environmental conditions. Real patterns of habitat loss are non-random, often clustered in space and within a subset of environmental conditions (e.

Differentiation of microbial communities in coastal seawater before and during an Akashiwo sanguinea (Dinophyceae) bloom in the urban area of Antofagasta city (northern Chile).

Harmful algal blooms (HABs) are highly relevant for public health, the economy, the ecosystem, and biodiversity stability in southern Chile (40° to 53°S), where they occur regularly and are frequently monitored. However, HAB events and their associated microbes in northern Chile (17° to 30°S) remain unknown and difficult to track due to a lack of monitoring, particularly in urban areas. We investigated changes in microbial communities in coastal seawater before and during an Akashiwo sanguinea bloom (B) at two sampling points in Antofagasta city (23°38'39S, 70°24'39W).

Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model.

Inflammation plays a key role in the development of neurodegenerative disorders that are currently incurable. Licochalcone A (LCA) has been described as an emerging anti-inflammatory drug with multiple therapeutical properties that could potentially prevent neurodegeneration. However, its neuroprotective mechanism remains unclear.

Leveraging Implementation Science to Identify and Address Facilitators and Barriers to WIC Enrollment, Participation, and Retention.

Background: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) supports the health and nutrition status of low-income pregnant and postpartum people and young children. Despite its numerous benefits, WIC faces low enrollment, participation, and retention.

Objectives: To identify facilitators and barriers to WIC enrollment, participation, and retention in Rhode Island, and develop an implementation blueprint to create tailored strategies to address barriers.