[Disorders of neurogenesis of cortical and subcortical structures in rat brain limbic system during fetal alcohol syndrome formation].

Disorders of neurogenesis of cortical and subcortical structures in rat brain limbic system were studied in the offspring of rats that received ethanol during pregnancy. The methods used included the staining of histological sections with cresyl violet, in vitro culture, and electron paramagnetic resonance. Prenatal alcohol intoxication was shown to induce the disturbances in proliferative activity of granular layer cells in the hippocampal dentate gyrus, neuron- and glioblast migration, enhancement of free NO and lipoperoxide production and cell death.

Effects of ethanol on neuron density in the limbic cortex of the brain and correction of evoked changes with the antioxidant Dolivin.

The aims of the present work were to measure neuron density in the limbic cortex in the offspring of female white rats given 15% ethanol solution during pregnancy and lactation and to address the possibility of correcting ethanol-induced impairments at the early stages of postnatal development (PND) using the antioxidant Dolivin. Neuron numbers were measured in the cingulate gyrus and entorhinal cortex on PND days 3, 7, 15, 21, and 30 (three animals in each age group). Dolivin (0.

[Investigation of oxidative stress-induced alterations in the rat brain cortical cellular culture and their correction with vitamines E and C].

The oxidative stress-induced changes and feasibility of prevention of these changes with an aid of vitamines E and C were investigated in cultured brain cortex of the newborn albino rats. Modeling the oxidative stress was achieved with addition of H(2)O(2) into the nutrient medium. In order to prevent an oxidative stress-induced cytotoxic effect, concomittantly with H(2)O(2), vitamines E and C were added into the nutrient medium.

[Effect of ethanol on the density of neuron disposition in limbic cerebral cortex and correction of induced changes with antioxidant Dolivin].

The purpose of this study was to determine the density of neuron disposition at the early stages of postnatal development of limbic cortex in the offspring of female rats, that consumed 15% ethanol solution during pregnancy and lactation period instead of water, and to detect the possibility of the correction of ethanol-induced changes with antioxidant Dolivin. The number of neurons in the cingulate girus and entorhynal cortex was determined at different stages of postnatal development (postnatal days 3, 7, 15, 21, 30). With an aim to correct ethanol-induced disorders, alcoholized females for the similar period of time, were given Dolivin (0.

Variations in the content of some trace elements and macroelements in the hippocampus of rats during learning and memory retrieval after destruction of the entorhinal cortex.

We studied variations in the concentration of Na, K, Ca, and Mg in the hippocampus of rats with damaged entorhinal cortex. The concentration of Mg, Na, K, and Ca remained practically unchanged, while the content of Zn and Cu increased during learning and memory retrieval in animals with damaged entorhinal cortex. Our results indicate that Zn and Cu, constituents of metalloproteins and metalloenzymes, play an important role in hippocampal function.