[Experimental basis for associated subcutaneous jet injection immunization against plague and smallpox].

Experiments in guinea-pigs have indicated that combined immunization with the mixture of live plague and smallpox vaccines introduced subcutaneously by means of a jet injector are safe and faintly reactogenic. Highly intense immunity, as revealed by serological shifts and by the degree of protection of the vaccinated animals challenge with the virulent cultures of the corresponding infective agents, allows the recommendation that combined subcutaneous immunization against plague and smallpox by means of a jet injector be further studied on humans.

[Ultrastructural changes in plague microbes of vaccinal strain EB and alveolar macrophages of guinea pigs during their interaction in vitro].

Aerosol immunization with plague vaccine EB was found to stimulate an increase in the number of free alveolar macrophages and to enhance their ingesting activity which correlated with an increase in specific antibody titers. Immunological transformation was accompanied by ultrastructural changes in the cytoplasm and the nuclei of alveolar macrophages. The phagocytosis of microbes occurred by their adsorption onto the microphage surface, invagination and enclosing into the endocytic bubble having the function of the digestive vacuole.