Publications by authors named "L G Danilova"
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations. We provide a reference single-cell dataset from tumor-infiltrating leukocytes (TILs) from a human neoadjuvant clinical trial comparing the granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic PDAC vaccine GVAX alone, in combination with anti-PD1 or with both anti-PD1 and CD137 agonist.
View Article and Find Full Text PDFSeven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) in the same city of Tyumen, Russia.
View Article and Find Full Text PDF[Psychopathological disorders at the onset of juvenile parkinsonism in childhood].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Article Synopsis
- The article details a case of a teenage girl diagnosed with juvenile parkinsonism caused by genetic mutations, showcasing the challenges in diagnosing and treating this condition alongside other psychiatric disorders.
- Despite years of psychiatric evaluations and treatments, clear symptoms of parkinsonism only emerged later, complicating the diagnosis.
- It emphasizes the need for a collaborative approach between psychiatrists and neurologists for accurate diagnosis and effective treatment in cases with overlapping symptoms.
Article Synopsis
- * In a Phase II clinical trial, 27 patients received entinostat followed by nivolumab, resulting in an objective response rate of 11% and a median response duration of over 10 months, although the primary endpoint for overall effectiveness was not reached.
- * The combination treatment led to significant immune profile changes, including increased dendritic cell activity and enhanced inflammatory response, suggesting potential for improving treatment strategies in PDA despite
Background: Brain metastases (BrMs) are a devastating complication of solid tumours. A better understanding of BrMs biology is needed to address their challenging clinical management.
Methods: Immunogenomic and digital spatial analyses were applied to interrogate the peripheral blood and tumour specimens derived from 53 unique patients with BrMs originating from different solid tumours.