Publications by authors named "L G Cockerham"
Sexual minority men are at increased risk for anal squamous cell carcinoma. Our objective was to compare screening engagement among individuals randomized to self-collect an anal canal specimen at home or to attend a clinic appointment. Specimen adequacy was then assessed for human papillomavirus (HPV) DNA genotyping.
View Article and Find Full Text PDFBackground: Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficiency virus (HIV) transcription in vitro. We aimed to determine whether circadian variation in HIV transcription exists in people with HIV (PWH) on antiretroviral therapy (ART).
Methods: We performed a prospective observational study of male PWH on ART, sampling blood every 4 hours for 24 hours.
Article Synopsis
- A pilot study was conducted to evaluate if adding lisinopril, an anti-fibrotic medication, to antiretroviral therapy (ART) could reverse gut tissue fibrosis and lower HIV levels in infected individuals.* -
- Thirty participants were randomly assigned to receive either lisinopril or a placebo for 24 weeks, with their HIV RNA and DNA levels in rectal tissue being the primary focus of measurement before and after the treatment period.* -
- Results showed that lisinopril did not significantly impact HIV levels, immune responses, or lymphoid fibrosis in participants, indicating a need for further research into other potential treatments for this condition.*
The fungi Paecilomyces variotii is a potential pathogen in immunocompromised and immunocompetent patients. Their rare association with clinical disease results in scarce literature regarding susceptibility and treatment. Here, we discuss a case involving successful treatment of probable P.
View Article and Find Full Text PDFBackground: Patient information leaflets (PILs) are often used to reinforce and provide further information relating to treatment choices, risks, and alternatives. An assessment of the quality of commonly used orthodontic patient information leaflets is lacking.
Methods: A cross-sectional assessment of patient information leaflets from two international orthodontic societies was undertaken.