Publications by authors named "L G Chirumamilla"

Article Synopsis
  • The study examines the rising rates of early onset colorectal cancer (EOCRC) among African American patients, highlighting significant differences between EOCRC (<45 years) and late-onset colorectal cancer (LOCRC) (>45 years) in terms of demographics and clinical presentation.
  • It found that EOCRC cases increased from just over 6% to over 13% of total CRC cases since 2010, with a higher family history of CRC and different symptom profiles, such as more abdominal pain and changes in bowel habits.
  • The study also noted that EOCRC patients had a higher rate of metastasis at diagnosis and took longer to undergo surgery compared to LOCRC patients.
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Background And Aim: Identifying clinical characteristics and outcomes of different ethnicities in the US may inform treatment for hospitalized COVID-19 patients. Aim of this study is to identify predictors of mortality among US races/ethnicities.

Design Setting And Participants: We retrospectively analyzed de-identified data from 9,873 COVID-19 patients who were hospitalized at 15 US hospital centers in 11 states (March 2020-November 2020).

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Patients with cancer are known to have a poor prognosis when infected with SARS-CoV-2 infection. We aimed in this study to assess health outcomes in COVID-19 patients with different cancers in comparison to non-cancer COVID-19 patients from different centers in the United States (US). We evaluated medical records of 1,943 COVID-19 Cancer patients from 3 hospitals admitted between December 2019 to October 2021 and compared them with non-cancer COVID-19 patients.

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Background: Coronavirus disease 2019 (COVID-19) manifest differently depending on patients' background and pre-existing conditions. It remains unclear how African Americans with cancer have been affected in comparison to those without. In this study, we aim to identify demographic, clinical, and laboratory markers associated with mortality in COVID-19 patients with cancer.

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Background: Long-COVID is a condition post SARS-CoV-2 infection with persistent or recurring symptoms affecting multiple organs, and may involve viral persistence, changes to the microbiome, coagulopathies, and alterations to neuro-immune interactions. These factors can disrupt the Gut-Brain Axis, which is a complex system involving bidirectional communication between the central nervous system and the gastrointestinal (GI) system. As a result of these disruptions, individuals with long-COVID may develop post-infectious functional GI disorders, which can cause a range of symptoms affecting the digestive system.

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