[Role of parotitis virus in the development of insulin-dependent diabetes mellitus].

Viral infection is one of the factors provoking the development of insulin-dependent diabetes mellitus (IDDM). Epidemic parotitis more frequently than other infections is connected with IDDM manifestations, but the results of examinations of convalescents after epidemic parotitis and of patients with newly diagnosed IDDM are contradictory. Parotitis viruses are believed to injure pancreatic beta-cells and trigger on the autoimmune process in carriers of certain antigens.

[Antigens of the HLA system in nodular formations of the thyroid gland].

Distribution of the HLA system Class 1 specificities was studied in 97 patients with thyroid carcinoma, 101 ones with nodular goiter and 500 donors in the Central Urals. B15, B18 antigens were very frequent and All antigens quite rare in the patients with thyroid carcinoma; in patients with nodular goiter the incidence of Aw19, A28, B18 antigens was the highest, whereas the incidence of A11 antigen and the A2-B35 haplotype was low. The groups of patients with thyroid carcinoma and nodular goiter differed only by the incidence of A28 antigen and A2-B35 haplotype, this fact indicating the immunogenetic similarity of the diseases in question.

[Individual immunogenetic characterization of patients with diffuse toxic goiter and autoimmune thyroiditis].

Statusmetry as a variant of a method of collective image recognition was used for evaluation of integral immunogenetic characterization of patients with toxic goiter (TG) and autoimmune thyroiditis (AT). Typing of 40 HLA antigens, class I, was performed in 114 TG patients, 106 AT patients and 500 healthy subjects, however this analysis employed the frequency of expression of 26 most informative specificities (9 alleles of locus A and 17 alleles of locus B of the HLA system). Functional models and decision rules to recognize TG, AT, remission and recurrence (decompensation) of TG were worked out.

[The HLA system in diffuse toxic goiter].

The paper is concerned with the determination of class I antigens of the HLA system in 104 patients with diffuse toxic goiter and in 643 donors. A study was made of the distribution of antigens, haplotypes and phenotypes of the HLA system. An increase in the frequency of antigens A28 and B8, haplotype [correction of haploptin] A1-B8 and phenotype B7, B8 and a decrease in the frequency of antigens B13, B17 and Cw4 were revealed.