Liquid Chromatography Column Screening for the Analysis of Corrosion Inhibitor Molecules Using Derringer Desirability Functions.

Corrosion inhibitors (CIs) are extensively employed in the oil and gas industry, yet their analysis remains a challenge. To develop a suitable liquid chromatography method for a wide array of CIs, a column screening was conducted. Nine different chromatographic conditions were tested across eight RPLC and mixed-mode columns (Accucore C18, CORTECS Shield RP18, Acquity HSS T3, Acquity Premier HSS T3, Accucore 150-C4, Accucore PFP, Synergi Polar RP, and Acclaim WCX-1).