Tracking malathion resistance in Spanish Ceratitis capitata populations: prevalence of resistance alleles/haplotypes before and after the withdrawal of malathion.

Background: Field resistance to malathion was reported for Mediterranean fruit fly (medfly), Ceratitis capitata, populations collected in Spain in 2004 and 2005, when medfly control mainly relied on malathion bait sprays. The mutation G328A in the acetylcholinesterase (AChE) gene (Ccace2) was then identified as the main resistance mechanism in a field-derived resistant strain. However, outdoor plant protection products containing malathion were withdrawn from the European Union in 2009 and other insecticides gained importance, such as spinosad and pyrethroids, though other organophosphates were occasionally used for medfly control for a few years.

Branched-chain amino acid catabolism promotes ovarian cancer cell proliferation via phosphorylation of mTOR.

Ovarian cancer is the sixth leading cause of cancer-related mortality among individuals with ovaries, and high-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype. Characterized by a distinct and aggressive metastatic pattern, HGSOC can originate in the fallopian tube with the transformation of fallopian tube epithelial (FTE) cells, which metastasize to the ovary and subsequently to the omentum and peritoneal cavity. The omentum is a privileged metastatic site, and the metabolic exchange underlying omental metastasis could provide enzyme or receptor targets to block spread.

Exploring Current Trends and Barriers in Integrating Substance Use Disorder Education Into the Physician Assistant/Associate Curriculum.

Introduction: The state of substance use disorder (SUD) training among US physician assistant/associate (PA) programs was last published in 2001. The purpose of this study was to provide an updated evaluation of the SUD training curriculum among Accreditation Review Commission on Education for the Physician Assistant (ARC-PA)-accredited PA programs. In addition, we will identify any potential barriers to implementing SUD education in either the didactic or clerkship curriculum.

Localizing the Seizure Onset Zone with Bayesian Learning During iEEG Monitoring.

A critical step in treating epilepsy patients is identifying the region where seizure activity originates: the seizure onset zone (SOZ). We present a novel approach to localizing the SOZ during ictal periods, i.e.

A resting-state fMRI network biomarker for autism spectrum disorder.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder impacting a person's social communication skills and behaviors. Due to its a wide range of symptoms and presentations, diagnosis is a subjective process reliant on clinician experience and symptom reports. Our pilot study aims to improve this process using a resting-state fMRI biomarker based on dynamic network modeling.