Publications by authors named "L Fratiglioni"
Article Synopsis
- A study in Stockholm investigated gender bias in diagnosing depression and prescribing antidepressants among older adults, revealing that older women are more likely to be diagnosed and treated compared to men.
- * The research utilized data from a national study, comparing clinical diagnoses based on official registers to a more nuanced diagnosis that considered various factors, yielding different results regarding gender bias.
- * Findings indicated that women had a significantly higher probability of receiving a depression diagnosis and antidepressant treatment, with the bias being more pronounced in younger individuals and those from higher socioeconomic backgrounds.
Objectives: This study aims to investigate the relationship between frailty and avoidable hospitalization risk, and the moderating role of sociodemographic, clinical, and care-related factors.
Design: Longitudinal population-based cohort study.
Setting And Participants: A total of 3168 community-dwelling individuals, aged ≥60 years, from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K).
Background: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with the risk of dementia across up to two decades' follow-up.
View Article and Find Full Text PDFBackground: We investigated the association of peak expiratory flow (PEF) with dementia; cognitive impairment, no dementia (CIND); and transition from CIND to dementia, and possible underlying neuropathological mechanisms.
Methods: A population-based cohort of adults aged 60+ was followed over 15 years to detect dementia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria), CIND (assessed through a cognitive battery), and progression from CIND to dementia, in relation to baseline PEF observations. A subsample (n = 462) had 6-year follow-up data on brain magnetic resonance imaging markers of neurodegeneration and small vessel disease.
Article Synopsis
- * A study analyzed 4,685 sporadic FTD cases and found significant genetic variants at the MAPT and APOE loci that increase the risk for the disease, indicating potential genetic overlap with other neurodegenerative diseases.
- * The genetic risk factors appear to vary by population, with MAPT and APOE associations predominantly found in Central/Nordic and Mediterranean Europeans, suggesting a need for further research into these population-specific features for better understanding of sporadic FTD.