Publications by authors named "L Franzini"

Article Synopsis
  • Early pressurized metered-dose inhalers (pMDIs) used chlorofluorocarbons (CFCs) as propellants, which harmed the ozone layer, leading to their phase-out under the 1987 Montreal Protocol.
  • Current pMDIs now use hydrofluoroalkanes (HFAs), like HFA-134a, which do not deplete ozone but contribute to global warming, prompting a gradual reduction in their use.
  • Instead of switching to dry powder inhalers (DPIs), which may not be suitable for all patients, an alternative is to reformulate pMDIs to use low-global warming potential propellants like HFA-152a, addressing environmental impact while considering patient
View Article and Find Full Text PDF

Introduction: Congenital heart disease (CHD) is the most common and resource demanding birth defect managed in the United States, with approximately 40,000 children undergoing CHD surgery year. Researchers have compared high-volume to low-volume hospitals and found significant hospital-level variation in major complications, health resource utilization, and health care costs after CHD surgery.

Materials And Methods: Using nationwide representative claim data from the United States Military Health System from 2016 to 2020, TRICARE beneficiaries diagnosed with CHD were tabulated based on ICD-10 codes (International Classification of Diseases, 10th revision).

View Article and Find Full Text PDF

Aims: Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown.

View Article and Find Full Text PDF

Background: Healthcare disparities are an issue in the management of Congenital Heart Defects (CHD) in children. Although universal insurance may mitigate racial or socioeconomic status (SES) disparities in CHD care, prior studies have not examined these effects in the use of High-Quality Hospitals (HQH) for inpatient pediatric CHD care in the Military Healthcare System (MHS). To assess for racial and SES disparities in inpatient pediatric CHD care that may persist despite universal insurance coverage, we performed a cross-sectional study of the HQH use for children treated for CHD in the TRICARE system, a universal healthcare system for the U.

View Article and Find Full Text PDF