Publications by authors named "L Fozzatti"
Anaplastic thyroid cancer (ATC) is a lethal endocrine malignancy. It has been shown that tumor-associated macrophages (TAMs) contribute to the aggressiveness of ATC. However, stimulatory factors that could facilitate the induction and infiltration of TAMs in the ATC tumor microenvironment (TME) are not fully elucidated.
View Article and Find Full Text PDFAnaplastic thyroid cancer (ATC) is a clinically aggressive form of undifferentiated thyroid cancer with limited treatment options. Tumor-associated macrophages (TAMs) constitute over 50% of ATC-infiltrating cells, and their presence is associated with a poor prognosis. We have previously shown that paracrine signals released by ATC cells induced pro-tumor M2-like polarization of human monocytes.
View Article and Find Full Text PDFSystemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus.
Microbes Infect
July 2024
Article Synopsis
- The thymus is essential for T cell differentiation, and its ability to resolve infections is affected by factors like inflammation and chronic infections.
- Inflammatory T helper 1 responses, particularly during infections like Candida albicans and Trypanosoma cruzi, can lead to mature single positive thymocytes and increased production of interferon gamma (IFNγ).
- CD44 cell presence in the thymus during T. cruzi infection indicates changes in T cell development and exportation that can be reversed in IFNγ knockout mice, suggesting that systemic inflammation impacts T cell maturation and susceptibility to diseases.
Introduction: Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory responses are implicated. The Aryl hydrocarbon receptor (AhR) plays a crucial role in regulating inflammation.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates cellular immunity responses against SARS-CoV-2 among patients in Córdoba, Argentina, during two distinct waves of the pandemic that featured different viral variants and social behavior.
- Findings reveal a disruption in lymphocyte populations, specifically noting an increase in B cells and a decrease in CD3 T cells compared to healthy donors, with a more significant reduction in Tregs among severe cases.
- Results suggest a potential new biomarker, the CD8/CD8 index, for predicting disease progression, as it correlated with increased severity while also showing altered effector cytokine production in T cell populations.