Publications by authors named "L Fourre"
Article Synopsis
- Disruption of the 9p21 locus in mesothelioma commonly leads to the loss of p16INK4a and p14ARF, prompting research into the potential of reintroducing p16INK4a using the HIV TAT delivery system to induce cancer cell death.
- A synthetic TATp16INK4a peptide was tested on mesothelioma cells, both in lab settings and in living organisms, showing significant inhibition of Cdk4, cell cycle arrest, and ultimately cell death.
- The study concludes that using TATp16INK4a, or similar small molecule strategies, may provide a promising treatment approach for mesothelioma by effectively inducing apoptosis and altering cell cycle progression.
Amplitude of the oral temperature circadian rhythm and the tolerance to shift-work.
J Physiol (Paris)
March 1980
The aim of the study was to test the hypothesis of a relationship between the tolerance to shift-work and the amplitude of the oral temperature circadian rhythm. Forty eight shift-workers (Rhône-Alpes Region) volunteered for this chronophysiological investigation: a) 23 steel-industry workers (SI); shift-duration: 7 days (weekly rotation); b) 25 chemical-industry workers (CI); shift-duration 2 days. The subjects' ages were roughly similar with regard to groups (SI and CI) as well as sub-groups (good and poor tolerance of shift-work).
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