Publications by authors named "L Fournel"
Article Synopsis
- Immunotherapy, particularly when combined with chemotherapy, has shown limited effectiveness against solid tumors due to factors like cancer cells promoting immune cell exhaustion through nutrient diversion in the tumor microenvironment (TME).
- The authors suggest using high doses of sodium citrate (SCT) alongside immune checkpoint inhibitors (ICIs) to inhibit cancer cell metabolism and enhance anti-tumor immune responses, as preclinical studies indicate SCT can reduce cancer growth and improve chemotherapy outcomes.
- SCT works by increasing available glucose for immune cells and lowering lactic acid levels in the TME, which may enhance T cell activity and repolarize macrophages, indicating its potential to significantly boost the effectiveness of current immunotherapies in clinical settings.
Introduction: The low incidence and heterogeneity of sarcomas limit understanding of their progression in metastatic cases. The use of metastasectomy is debated due to lack of consensus and evidence-based data. This study aimed to identify simple prognostic factors that could contribute to the therapeutic strategy.
View Article and Find Full Text PDFIntroduction: Small-cell lung carcinoma (SCLC) is a high-grade neuroendocrine carcinoma of poor prognosis. Although immune checkpoint blockers have shown promising results in advanced SCLC, the tumor immune microenvironment (TME) remains poorly understood, with no validated prognostic or predictive biomarkers of efficacy.
Methods: This retrospective study included surgically samples from 48 SCLC patients between 2009 and 2018.
Article Synopsis
- The study aimed to assess how well artificial intelligence (AI) can detect lung metastases in preoperative CT scans compared to radiologists.
- AI was applied to CT scans of 167 patients, showing that it detected a high percentage of true nodules and significantly improved the overall sensitivity when used alongside human radiologists.
- The findings suggest that AI not only enhances detection rates but can also identify cancers earlier, which could be beneficial for patient care.
A surgical series on endometriosis-related diaphragmatic hernia.
Gen Thorac Cardiovasc Surg
October 2024
Background: Thoracic endometriosis syndrome gives rise to various clinical and radiological manifestations. We reviewed the records of patients operated for intrathoracic migration of abdominal viscera through a diaphragmatic hernia secondary to thoracic endometriosis.
Methods: We retrospectively reviewed the single-center prospective collected database of all patients operated for thoracic endometriosis during the twenty years.