Publications by authors named "L Fokdal"
Background And Purpose: The similarities in biology, treatment regimens and outcome between the different human papillomavirus (HPV) associated squamous cell carcinomas (SCCs) allow for extrapolation of results generated from one SC tumor type to another. In HPV associated cancers, HPV is integrated into the tumor genome and can consequently be detected in the circulating fragments of the tumor DNA. Thus, measurement of HPV in the plasma is a surrogate for circulating tumor DNA (ctDNA) and holds promise as a clinically relevant biomarker in HPV associated cancers.
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- The management of advanced ovarian cancer (AOC) has improved due to molecular diagnostics that help predict how patients will respond to PARP inhibitors, particularly based on homologous recombination deficiency (HRD) status.
- This study analyzed tumor samples from a clinical trial to investigate why HRD status isn't always a reliable indicator of sensitivity to PARP inhibitors.
- Key findings included that some HRD-negative samples showed responses to treatment despite their status, while some HRD-positive samples did not, emphasizing the need to consider other genetic factors beyond HRD status.
Article Synopsis
- A study examined the outcomes of 3723 Danish patients with endometrial cancer who underwent radical surgery without adjuvant radiotherapy from 2005-2012 to assess the impact on recurrence patterns and potential benefits of adjuvant treatment.
- Results showed a 13.4% recurrence rate over nine years, with non-low-risk patients experiencing higher rates of isolated vaginal (6.7%) and pelvic recurrences (2.1%) compared to low-risk patients, who had rates of 2.9% and 0.8%, respectively.
- The findings suggest that while the omission of adjuvant radiotherapy appears safe, it may have prevented isolated local recurrences in 8.7% of non-low
Purpose And Objective: Squamous cell carcinoma of the anal margin (SCCAM) is an uncommon lesion that comprises one-third to a quarter of all anal squamous cell carcinoma. Treatment involves surgery or exclusive radiotherapy for small tumours, whereas the preferred treatment for larger tumours is chemoradiotherapy. In our department, selected patients with SCCAM are treated with electron beam radiotherapy using one perineal field.
View Article and Find Full Text PDFBackground: Secondary lymphedema is a known side effect to radiotherapy (RT), but limited information regarding prevalence and risk factors for lower limb edema (LLE) after curative radiotherapy in patients with prostate cancer (PCa) is available. This study provides a descriptive analysis of patient-reported LLE with analysis of risk factors in a cohort of patients with PCa treated with curative RT.
Material And Methods: A total of 302 patients with PCa with prospective registration of patient-reported LLE (EORTC QLQ-PR25 (Question 46)) were included.