Publications by authors named "L Fiebig"
Article Synopsis
- A systematic review was conducted by the European Space Agency to evaluate how effective passive countermeasures are in reducing health issues caused by weightlessness in space, specifically focusing on the heart, lungs, and muscles.
- The review included 16 studies out of 647 screened articles and aimed to assess the effectiveness of interventions like lower body negative pressure, whole body vibration, skin surface cooling, and centrifugation on astronaut health during long-term missions.
- Results indicated that while some countermeasures showed positive effects, such as maintaining orthostatic tolerance and balance, many did not significantly improve cardiovascular fitness compared to control groups, indicating a need for more effective solutions for future space missions.
Background: SARS-CoV-2 specific antibody-secreting plasma cells (PC) mediating specific humoral immunity have been identified in the human bone marrow (BM) after COVID-19 or vaccination against SARS-CoV-2. However, it remained unclear whether or not they acquire phenotypes of human memory plasma cells.
Methods: SARS-CoV-2-specific human bone marrow plasma cells (BMPC) were characterised by tetramer-based, antigen-specific flow cytometry and FluoroSpot assay.
Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans.
Eur J Drug Metab Pharmacokinet
July 2023
Background And Objectives: Current anticoagulants pose an increased risk of bleeding. The development of drugs targeting factor XIa, like asundexian, may provide a safer treatment option. A human mass‑balance study was conducted to gain a deeper understanding of the absorption, distribution, metabolism, excretion, and potential for drug-drug interaction of asundexian.
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- * The method's working ranges were established at 0.5-500 ng/ml for asundexian and 5.0-5000 ng/ml for M-10, meeting all necessary validation guidelines.
- * Clinical analysis showed that the method was accurate, precise, selective, and reproducible, making it effective for analyzing samples from clinical trials.