Fluoroquinolone-Related Neuropsychiatric Events in Hospitalized Veterans.

Objective: To measure the incidence and risk factors for fluoroquinolone (ciprofloxacin, moxifloxacin, and levofloxacin)-associated psychosis or delirium in a veteran population.

Methods: A retrospective study was conducted in the Western New York Veterans Affairs Health System (2005-2013). Participants were hospitalized veterans receiving a fluoroquinolone for at least 48 hours (n = 631).

Evidence of a clinically significant interaction between warfarin and intravesical gemcitabine.

Purpose: A case of supratherapeutic International Normalized Ratio (INR) values and hematomas subsequent to concomitant administration of warfarin and intravesical gemcitabine is reported.

Summary: A 90-year-old man with bladder cancer refractory to bacillius Calmette-Guérin was diagnosed with deep vein thrombosis (DVT) and started on warfarin one month before starting treatment with intravesical gemcitabine 2 g (one dose per week for six weeks). Before intravesical gemcitabine was started, the patient reached consecutive therapeutic INR values.

Strongly stretched protein resistant poly(ethylene glycol) brushes prepared by grafting-to.

We present a new grafting-to method for resistant "non-fouling" poly(ethylene glycol) brushes, which is based on grafting of polymers with reactive end groups in 0.9 M Na2SO4 at room temperature. The grafting process, the resulting brushes, and the resistance toward biomolecular adsorption are investigated by surface plasmon resonance, quartz crystal microbalance, and atomic force microscopy.

Highly directional bottom-up 3D nanoantenna for visible light.

Controlling light at the nanoscale is of fundamental importance and is essential for applications ranging from optical sensing and metrology to information processing, communications, and quantum optics. Considerable efforts are currently directed towards optical nanoantennas that directionally convert light into strongly localized energy and vice versa. Here we present highly directional 3D nanoantenna operating with visible light.

Material-selective surface chemistry for nanoplasmonic sensors: optimizing sensitivity and controlling binding to local hot spots.

Optical sensors utilizing the principle of localized surface plasmon resonance (LSPR) offer the advantage of a simple label-free mode of operation, but the sensitivity is typically limited to a very thin region close to the surface. In bioanalytical sensing applications, this can be a significant drawback, in particular since the surface needs to be coated with a recognition layer in order to ensure specific detection of target molecules. We show that the signal upon protein binding decreases dramatically with increasing thickness of the recognition layer, highlighting the need for thin high quality recognition layers compatible with LSPR sensors.