The Effect of Multimodal Prehabilitation on Postoperative Outcomes in Lung Cancer Surgery.

Objective: Lung cancer patients are often elderly, frail, smokers with poor functional reserve, making them excellent candidates for multimodal prehabilitation to improve postoperative outcomes. Patients referred to the prehabilitation clinic are at even higher surgical risk. This retrospective observational study aimed to compare the postoperative 30-day outcomes in lung cancer surgery between the propensity score matched patients.

Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers.

Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by IBD patient-derived colon epithelial cells interfaced with matched fibroblasts cultured under flow. Use of heterotypic tissue recombinants revealed that IBD fibroblasts are the primary drivers of multiple IBD symptoms.

Translation of genomics into routine cardiological practice: insights from a European Society of Cardiology Cardiovascular Round Table.

Cardiovascular diseases (CVD) remain the leading cause of death globally and there is an urgent need for innovative approaches to treatment. One emerging avenue is genetic therapies, which hold particular promise for diseases with a monogenic basis. Gene silencing techniques using antisense oligonucleotides or ribonucleic acid interference strategies are currently at the forefront of genetic therapies in CVD, with several ribonucleic acid-targeted therapies already approved for the treatment of conditions such as familial hypercholesterolaemia and transthyretin amyloidosis.