Synthesis and Biological Evaluation of New -Restricted Triazole Analogues of Combretastatin A-4.

The natural products combretastatins A-1 and A-4 are potent antimitotic and vascular-disrupting agents through their binding at the colchicine site in tubulin. However, these compounds suffer from a low water solubility and a tendency to isomerize to the inactive stilbenes. In this study, we have prepared a series of 18 -restricted triazole analogues of combretastatin A-4 (CA-4), maintaining, in all cases, the 3,4,5-trimethoxy phenyl ring A, with the aim of investigating the substitution pattern on the B-ring in a systematic way.

The ReAct project: Analysis of data from 23 different laboratories to characterise DNA recovery given two sets of activity level propositions.

The ReAct (Recovery, Activity) project is an ENFSI (European Network of Forensic Science Institutes) supported initiative comprising a large consortium of laboratories. Here, the results from more than 23 laboratories are presented. The primary purpose was to design experiments simulating typical casework circumstances; collect data and to implement Bayesian networks to assess the value (i.

The impact of parameter variation in the quantification of forensic genetic evidence.

Technological advancements have allowed the detection of increasingly complex forensic genetics samples, as minimum amounts of DNA can now be detected in crime scenes or other settings of interest. The weight of the evidence depends on several parameters regarding the population and sample-related analytical factors, the latter in a greater number when the DNA amount is considered. This led to the development of probabilistic genotyping software (PGS), able to deal with the associated complexities.

Rhizostomes as a resource: The expanding exploitation of jellyfish by humans.

While jellyfish are often considered to be a nuisance, their value to ecosystems and for human exploitation is shifting this perception. People have been eating jellyfish for millennia. In recent decades, the scale of jellyfish fisheries has expanded dramatically, with annual catches in the hundreds of thousands of tonnes.