Publications by authors named "L Fava"
We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.
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- The study investigates the processes e^{+}e^{-}→D_{s}^{+}D_{s1}(2536)^{-} and e^{+}e^{-}→D_{s}^{+}D_{s2}^{*}(2573)^{-} using data from the BESIII detector, focusing on a range of center-of-mass energies.
- For the first time, the absolute branching fractions of the decay processes for D_{s1}(2536)^{-} and D_{s2}^{*}(2573)^{-} are measured, revealing values of 35.9% and 37.4% respectively.
- The research identifies a resonant structure around 4.6 Ge
Centrosomes are membrane-less organelles that orchestrate a wide array of biological functions by acting as microtubule organizing centers. Here, we report that caspase-2-driven apoptosis is elicited in blood cells failing cytokinesis and that extra centrosomes are necessary to trigger this cell death. Activation of caspase-2 depends on the PIDDosome multi-protein complex, and priming of PIDD1 at extra centrosomes is necessary for pathway activation.
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- The RNA binding protein HuR is crucial for regulating the innate immune response, and blocking it can have positive anti-inflammatory outcomes.
- A new series of small molecules, Tanshinone Mimics (TMs), were developed to disrupt HuR-RNA binding, with furan-containing compound 5/TM11 proving to be the most effective in inhibiting this interaction.
- Compound 5/TM11 not only enhances solubility but also selectively decreases cell proliferation in macrophages at certain doses, leading to a significant reduction in proinflammatory cytokines in response to LPS.
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research when looking for targeted therapies. We discovered cyclin C as a key factor for B-ALL development and maintenance.
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