Exploring the Landscape of Pre- and Post-Synaptic Pediatric Disorders with Epilepsy: A Narrative Review on Molecular Mechanisms Involved.

Neurodevelopmental disorders (NDDs) are a group of conditions affecting brain development, with variable degrees of severity and heterogeneous clinical features. They include intellectual disability (ID), autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), often coexisting with epilepsy, extra-neurological comorbidities, and multisystemic involvement. In recent years, next-generation sequencing (NGS) technologies allowed the identification of several gene pathogenic variants etiologically related to these disorders in a large cohort of affected children.

How interpersonal distance varies throughout the lifespan.

Interpersonal Distance (IPD) is defined as the physical distance that individuals maintain between themselves and others during social interactions. While literature has extensively focused on this everyday social behavior, how IPD changes throughout the lifespan remains an open question. In this study, 864 participants, aged 3-89 years, performed the Stop Distance Paradigm in their real-life environments, and we measured the distance they kept from both familiar and unfamiliar others during social interactions.

Cooperation and competition have same benefits but different costs.

Cooperation and competition shape everyday human interactions and impact individuals' chances of success in different domains. Using a virtual Stroop test, classically employed to assess general cognitive interference, we examined the impact of social context (cooperation and competition) and other's ability (higher and lower performers) on performance, perceived stress, and autonomic activity. In Experiment 1, we found that both cooperation with a lower performer and competition with a higher performer led to similar enhancement in performance.

Autoregulation Does Not Provide Additional Benefits to a Mixed Session Periodized Resistance Training Program in Trained Men.

Bartolomei, S, Francesco, L, Latini, D, and Hoffman, JR. Autoregulation does not provide additional benefits to a mixed session periodized resistance training program in trained men. J Strength Cond Res 38(9): 1535-1542, 2024-The aim of this investigation was to study how autoregulation impacted training volume, performance, and muscle size on a 10-week mixed session periodized (MSP) resistance training program, characterized by the inclusion of different training foci in each session.

An Accelerometer-Based Wearable Patch for Robust Respiratory Rate and Wheeze Detection Using Deep Learning.

Wheezing is a critical indicator of various respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD). Current diagnosis relies on subjective lung auscultation by physicians. Enabling this capability via a low-profile, objective wearable device for remote patient monitoring (RPM) could offer pre-emptive, accurate respiratory data to patients.