A Simple Kit for the Good-Manufacturing-Practice Production of [Ga]Ga-EDTA.

Glomerular filtration rates for individual kidneys can be measured semi-quantitatively by a gamma camera using [Tc]Tc-DTPA, with limited diagnostic accuracy. A more precise measurement can be performed on a PET/CT scanner using the radiotracer [Ga]Ga-EDTA, which has been validated in animal studies. The purpose of this study was to develop an easy kit-based synthesis of [Ga]Ga-EDTA that is compliant with good manufacturing practice (GMP) and applicable for human use.

Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-C]β-hydroxybutyrate ([C]OHB) PET in healthy humans.

Background: Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the brain and the kidneys. Drug treatments, dietary regimens and oral ketone drinks designed to deliver ketones for organ and tissue energy production have therefore gained popularity. However, whether ingested ketones are taken up by various extra-cerebral tissues and to what extent is still largely unexplored.

Recovery of Gallium-68 and Zinc from HNO-Based Solution by Liquid-Liquid Extraction with Arylamino Phosphonates.

The cyclotron production of gallium-68 via the Zn()Ga nuclear reaction in liquid targets is gaining significant traction in clinics. This work describes (1) the synthesis of new arylamino phosphonates via the Kabachnik-Fields reaction, (2) their use for liquid-liquid extraction of Ga from 1 M Zn(NO)/0.01 M HNO in batch and continuous flow, and (3) the use of Raman spectroscopy as a process analytical technology (PAT) tool for in-line measurement of Zn.

NANOCIS®: Possible errors in the summary of product characteristics quality control method and a suggested alternative method.

Background: Determination of the radiochemical purity of [Tc]NANOCIS® was performed using the procedure described in the Summary of Product Characteristics (SPC). In contrast to the clinical findings of thyroid gland accumulation indicating free [Tc] pertechnetate, the QC results showed no free [Tc]pertechnetate. This discrepancy prompted us to further investigate the described QC procedure.

Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model.

Background: The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour model to investigate whether endothelial outgrowth cells (EOCs) influenced the short term treatment efficiency of combretastatin A-4 disodium phosphate (CA4P) and 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by increasing EOC tumour recruitment.

Methods: In order to visualize the recruitment of EOCs to the tumours, umbilical cord blood derived human EOCs were labelled with 111Indium-tropolone in a dose of 0.