Publications by authors named "L Fajardo"
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious disease with devastating effects on the global pig industry. This warrants the development of effective control strategies, such as vaccines. However, previously developed inactivated vaccines have proven ineffective, while live-attenuated vaccines carry inherent safety risks.
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- A retrospective cohort study assessed five-year survival rates of patients with sleep apnea (SA) in Colombia from 2005 to 2022, focusing on variables like age, sex, and comorbidities.
- The overall five-year survival rate was 94.6%, with significant decreases for individuals over 65 (88.5%) and those with cardiovascular disease (89%).
- Key risk factors linked to decreased survival included older age, male sex, cardiovascular diseases, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), and metastatic cancer.
Advancing one health vaccination: In silico design and evaluation of a multi-epitope subunit vaccine against Nipah virus for cross-species immunization using immunoinformatics and molecular modeling.
PLoS One
September 2024
Article Synopsis
- * A multi-epitope subunit vaccine was designed using immunoinformatics and molecular modeling, targeting humans and intermediate hosts like swine and equine to trigger immune responses.
- * The final vaccine design, combined with the RpfE adjuvant, showed promising stability and potency in stimulating antibody production, outperforming existing vaccine designs, but further testing is needed to confirm its effectiveness.
Background: Porcine epidemic diarrhea (PED), caused by the porcine epidemic diarrhea virus (PEDV), is associated with high mortality and morbidity rates, especially in neonatal pigs. This has resulted in significant economic losses for the pig industry. PEDV genotype II-based vaccines were found to confer better immunity against both heterologous and homologous challenges; specifically, spike (S) proteins, which are known to play a significant role during infection, are ideal for vaccine development.
View Article and Find Full Text PDFContrast-enhanced mammography (CEM) is an emerging breast imaging technology with promise for breast cancer screening, diagnosis, and procedural guidance. However, best uses of CEM in comparison with other breast imaging modalities such as tomosynthesis, ultrasound, and MRI remain inconclusive in many clinical settings. This review article summarizes recent peer-reviewed literature, emphasizing retrospective reviews, prospective clinical trials, and meta-analyses published from 2020 to 2023.
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