Publications by authors named "L Fahy"
Aim: To define the association between severe coronary artery disease and widespread atherosclerosis in younger individuals.
Methods: Individuals aged 1-50 years with sudden cardiac death (SCD) from 2019-23, autopsy-proven to be due to coronary artery disease, were identified using the state-wide EndUCD registry. Presence of extra-coronary atherosclerosis greater than modified American Heart Association class III was assessed in 5 arterial beds (intra-cerebral vessels, aorta, carotid, renal and femoral arteries).
Background: In patients with preserved left ventricular ejection fraction (LVEF), small ventricular size has been associated with reduced functional capacity, but its impact on clinical outcomes is unclear.
Objectives: The goal of this study was to determine the relationship between small heart size and premature mortality within a large multicenter adult patient cohort with transthoracic echocardiographic examinations.
Methods: We divided 366,484 individuals with LVEF ≥50% (including a subset of 279,442 individuals with high-normal LVEF ≥60%) by sex and increasing quartiles for LV end-diastolic volume (LVEDV), LVEDV indexed to body surface area (LVEDVi), and LV end-diastolic diameter to assess associations with 5-year mortality through linkage with the National Death Index.
Article Synopsis
- The study examines the use of do-not-resuscitate (DNR) orders in patients aged 60 and older during out-of-hospital cardiac arrests (OHCA) in Victoria, Australia, over a 15-year period.
- Of the 47,322 older patients, only 5.7% had DNR orders, and only 12.4% of those orders were communicated to emergency services.
- Bystanders initiated resuscitation in 40% of cases, but only a small fraction of patients transported to the hospital survived, highlighting the need for better communication and respect for patients' wishes regarding DNR orders.
Article Synopsis
- - This case highlights the challenges in predicting outcomes for athletes with valvular disease, as their athletic training can alter normal heart function.
- - A 46-year-old female athlete is mentioned, who has both a bicuspid aortic valve and a subaortic membrane, leading to significant heart valve issues but no noticeable symptoms.
- - The study suggests that cardiopulmonary exercise testing and advanced imaging techniques can be valuable tools for evaluating and managing condition in athletes.
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disorder characterized by an increased proliferation of immature T lymphocytes precursors. T-ALL treatment includes chemotherapy with strong side effects, and patients that undergo relapse display poor prognosis. Although cell-intrinsic oncogenic pathways are well-studied, the tumor microenvironment, like inflammatory cellular and molecular components is less explored in T-ALL.
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