Bortezomib decreases Rb phosphorylation and induces caspase-dependent apoptosis in Imatinib-sensitive and -resistant Bcr-Abl1-expressing cells.

The use of c-abl-specific inhibitors such as Imatinib (IM) or Dasatinib has revolutionized the treatment of chronic myeloid leukemia (CML). However, a significant percentage of patients become resistant to IM. In this report, we have analyzed the possibility of using the proteasome as a molecular target in CML.

[Improvement of endoscopic resection procedures in relation to the volume of prostatic adenoma].

First choice therapy of obstructive prostatic hyperplasia is still represented by endoscopic transurethral resection of the prostate, despite new techniques for tissue ablation have being proposed. The issue aims to answer to the questions arising about indications of this procedure, and introduces to the knowledge of physical laws which regulate irrigation during and after operation and to the different techniques of irrigating flow derivation whose application reduced morbidity depending on tissue volume and "resection time". Moreover, the new technique of continuous resection with simultaneous suprapubic evacuation of tissue chips (Turbo-TUR) will be illustrated in details, as it permitted to extend indications and advantages of endoscopic surgery to bulky adenomas, electively submitted to open surgery up to now.

[The diagnosis of mental disorders by the primary care physician].

Objectives: To determine the percentage of psychiatric disorders recognised by primary care doctors and what influence the reason for consultation exerts on the psychiatric diagnosis.

Design: A crossover study of the prevalence of psychopathology. A two-phase study was performed, with systematic sampling of one in every four visits.

[Prevalence of psychopathology at a primary care center].

Objectives: To determine the prevalence of psychopathology among those attending a primary care centre and discover its diagnostic distribution using the criteria of the DSM-III-R.

Design: A crossover study of the prevalence of psychopathology. A two-phase study was performed by systematic sampling of one of every four visits.

[Initial experiences in the treatment of benign prostatic hypertrophy with laser (side firing)].

After a short literature review about the topic, the AA. present a 6 months follow up of 15 patients treated with prolase II fiber (cytocare) for BPH. In 80% we got good results about the symptom score and urinary flow, but at the endoscopic control in some cases we found an irregularity in the prostatic urethral as there was some prostatic residual tissue.