Publications by authors named "L F Wolff"
The activity level and specific behaviours exhibited by captive animals are crucial indicators of welfare. Stereotypies, or repetitive behaviours that have no apparent function or goal, are performed by animals experiencing poor conditions in their environment and indicate welfare concerns. Changes in the housing environment in particular may have critical influences on behaviour and welfare.
View Article and Find Full Text PDFObjectives: This study aimed to assess (1) effects of abatacept on salivary gland histology of Sjögren's disease (SjD) patients, (2) the predictive value of salivary gland histopathological characteristics at baseline for clinical response to abatacept treatment.
Methods: Patients (n=41) who participated in the Dutch ASAP-II and ASAP-III trials and international abatacept trial (IM101603) from whom a labial (n=13) or parotid (n=28) salivary gland biopsy was obtained at baseline and after 24 weeks of treatment with abatacept were included. Biopsies were analysed for SjD related histopathological features before and after abatacept (n=25) or placebo (n=16) treatment.
Article Synopsis
- The study aimed to evaluate the modified Short Questionnaire to Assess Health enhancing physical activity (mSQUASH) in patients with Sjögren's disease (SjD) and other rheumatic diseases, focusing on its validity and reliability.
- Researchers conducted interviews with different patient groups to ensure the mSQUASH was understood and relevant, finding fair correlations with other health measures and overall good test-retest reliability.
- Results suggest the mSQUASH is a valid and reliable tool for assessing daily physical activity in patients with SjD, indicating it can effectively measure exercise levels in this population.
VEXAS syndrome, a monogenic X-linked disorder resulting from mutations in the UBA1 gene, has emerged as a key model for unraveling the links between systemic inflammatory or autoimmune diseases (SIAD) and myelodysplastic syndromes (MD). This syndrome is characterized by the presence of vacuoles, X-linked inheritance, autoinflammation, and somatic mutation patterns, highlighting a unique intersection between genetic and immunological dysregulation. Apart from VEXAS, 10% to 30% of individuals diagnosed with MDS exhibit SIAD phenotypes, a significant increase compared to the 5% incidence in the general population.
View Article and Find Full Text PDFArticle Synopsis
- Cutaneous sclerosis is a condition where there is an abnormal increase of dermal or hypodermal elements, leading to skin thickening and hardening.
- It is commonly linked with systemic sclerosis but can also appear in various lesser-known syndromes that show a wide range of symptoms.
- The article discusses the causes, symptoms, and potential treatment options for these rare skin conditions.