Publications by authors named "L F Williams"
Outcomes of Mechanical Circulatory Support Devices Among Patients with Mechanical Complications of Acute Myocardial Infarction.
Eur Heart J Acute Cardiovasc Care
March 2025
Background: Mechanical complications of acute myocardial infarction (AMI) are rare but associated with considerably high mortality. While guidelines suggest mechanical circulatory support (MCS) devices as a potential bridge to definitive therapy, studies supporting this recommendation are limited.
Methods: Using data from the National Inpatient Sample, a large admirative database in the United States, years 2016-2020, we identified AMI admissions (ST-elevation and non-ST-elevation myocardial infarction) with mechanical complications (ventricular septal defect, free wall rupture, or papillary muscle rupture).
Background: We previously identified a cognitive biotype of depression characterized by dysfunction of the brain's cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC), derived from functional magnetic resonance imaging (fMRI). We evaluate these circuit metrics as personalized predictors of antidepressant remission.
Methods: We undertook a secondary analysis of data from the international Study to Predict Optimized Treatment in Depression (iSPOT-D) for 159 patients who completed fMRI during a GoNoGo task, 8 weeks treatment with one of three study antidepressants and who were assessed for remission status (Hamilton Depression Rating Scale score of ≤ 7).
Aims: Plasma metabolites are prognostic in heart failure with reduced ejection fraction (HFrEF), with citric acid cycle metabolites linked to ejection fraction (EF) changes. We investigated these mechanisms in a canine chronic HFrEF model. We tested associations between changes in plasma metabolites, left ventricular (LV) end-diastolic volume and cardiomyocyte mitochondrial function.
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