CTP-defined collaterals is a better predictor of intracranial atherosclerotic stenosis-related large-vessel occlusion than multiphase CTA-defined collaterals.

The optimal neuroimaging modalities for differentiating intracranial atherosclerotic stenosis-related large vessel occlusion (ICAS-LVO) from embolism related LVO remain uncertain. This study aimed to address this question by directly comparing collateral circulation using either baseline CT perfusion (CTP) or multiphase CT angiogram (mCTA) to define collaterals. We retrospectively analyzed consecutive patients with acute large vessel occlusion from October 2021 to December 2023.

Chinese Guidelines on the Management of Hepatic Encephalopathy in Cirrhosis (2024).

With progress in basic and clinical research on hepatic encephalopathy in cirrhosis worldwide, the Chinese Society of Hepatology of the Chinese Medical Association has invited experts in relevant fields to revise the 2018 "Chinese Guidelines on the Management of Hepatic Encephalopathy in Cirrhosis." The updated guidelines provide recommendations for the clinical diagnosis, treatment, and both primary and secondary prevention of hepatic encephalopathy in cirrhosis.

UMPPI: Unveiling Multilevel Protein-Peptide Interaction Prediction via Language Models.

Protein-peptide interactions are essential to cellular processes and disease mechanisms. Identifying protein-peptide binding residues is critical for understanding peptide function and advancing drug discovery. However, experimental methods are costly and time-intensive, while existing computational approaches often predict interactions or binding residues separately, lack effective feature integration, or rely heavily on limited high-quality structural data.

Potential Genetic Markers Associated with Environmental Adaptability in Herbivorous Livestock.

Herbivorous livestock, such as cattle, sheep, goats, horses, and donkeys, play a crucial role in agricultural production and possess remarkable resilience to extreme environmental conditions, driven by complex genetic mechanisms. Recent advancements in high-throughput sequencing, genome assembly, and environmental data integration have enabled a deeper understanding of the genetic basis of their environmental adaptation. This review identifies key genes associated with high-altitude, heat, cold, and drought adaptation, providing insights into the molecular mechanisms underlying these traits.

Sleep disturbances among older adults from the Russian Far East experiencing social loss: is there a sex difference?

Background: Maintaining sleep health in the elderly is of great significance for promoting health equity. The elderly usually experience more social losses, which may lead to many health problems. Few studies have revealed the relationship between social losses and sleep disturbance in the elderly.