Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives.

This work describes the synthesis and biological evaluation of hitherto unknown N-arylspermidine derivatives 3. Compounds 3 were efficiently prepared from cyclic amidines through a novel synthetic approach comprising alkylation with ω-halonitriles followed by reduction. The cyclic N-arylamidine directs the alkylation to the unsubstituted nitrogen and also provides the N-benzyl group present in the triamine after simultaneous reduction of the resulting quaternary salt 2 and the cyano group.

Susceptibility of solitary bees to agrochemicals highlights gaps in bee risk assessment.

Ground-nesting solitary bees are the most abundant bee species in the xeric areas of the world, but the effects of agrochemicals on them have been little studied. Herein, we evaluated the topical toxicity of an insecticide, a herbicide, and an essential oil on Mediterranean ground-nesting bees (Andrena impunctata, Andrena nigroolivacea, Andrena stabiana, Andrena vetula), and on the managed Apis mellifera, Bombus terrestris, and Osmia bicornis. We tested the lethal effects of commercial formulations of acetamiprid, glyphosate and a biopesticide based on sweet orange essential oil, and evaluated the locomotor behaviours of managed bees exposed to the same treatments.

Point-of-care ultrasonography for diagnosis of purulent pericarditis postappendectomy: a case report.

Purulent pericarditis is rare condition in the modern era of antibiotics. However, it is a serious condition as it has an accelerated progression and is difficult to diagnose due to its nonspecific clinical presentation, resulting in high mortality. Herein, we present a case in which a 36-year-old male patient with otherwise unremarkable medical history developed abdominal sepsis complicated by purulent pericarditis post-appendectomy.

Setting of residue definitions and toxicological reference values for ethiprole.

In accordance with Article 6 of Regulation (EC) No 396/2005, the original evaluating Member State (EMS), the United Kingdom, received an application from Bayer CropScience to set an import tolerance for the non-approved active substance ethiprole in rice. In the framework of the assessment process, the application was re-allocated to the Netherlands and the purpose of the application was changed to only set European residue definitions and toxicological reference values for the active substance ethiprole. Based on the assessment of the available toxicological data, an acceptable daily intake of 0.