[Visceral lesions in alcoholism].

Rich clinical material has been gained on carbohydrate and lipid metabolisms, cardiovascular, hepatic, pancreatic, gastric parameters in chronic alcoholics. Functional and morphological changes correlated with duration of chronic alcoholism. No definite relationship existed between the stage of alcoholism and alterations in laboratory and instrumental findings in the course of abstinence syndrome.

[Hepatopancreatic syndrome in chronic alcoholism].

The results of puncture biopsy of the liver, ultrasonic and angiographic investigation of the liver and pancreas in 114 patients with chronic alcoholism revealed an increment of changes in these organs in parallel with an increase in the duration of chronic alcoholic intoxication. A simultaneous study of immunoreactive insulin (IRI) and C-peptide showed that an increase in the IRI basal level in the patients suffering from alcoholism up to 10 yrs was determined mainly by an increase in the activity of beta-cells. In a long period of alcoholism an increase in the IRI basal level resulted from a decrease in the rate of insulin degradation in the liver as assessed by a lower level of C-peptide.