[The markers of dysfunction of endothelium and cytokine profile in patients with metabolic syndrome and abdominal obesity.].

The publications of Russian and foreign researcher are described the alterations of cellular and humoral chain of immunity under obesity and metabolic syndrome. However, the presented facts are in many ways contradictory. The data concerning the level of markers of dysfunction of endothelium and indices of immune status in patients with isolated abdominal obesity is absent in available literature.

Antioxidant Effect of Erythropoietin during Experimental Chronic Renal Failure.

The effects of erythropoietin (Epokrin, 900 U/kg) on the parameters of free radical oxidation in the plasma and lymphocytes of peripheral blood were studied in rats with chronic renal failure. We observed accumulation of primary (diene conjugates) and secondary (ketodienes, and conjugated trienes) LPO products in the heptane and isopropanol fractions of blood plasma and a decrease in superoxide dismutase and catalase activities in blood plasma. In lymphocytes, the concentration of primary, secondary and end-products (Schiff bases) of LPO increased in the isopropanol fraction of lipid extract.

Effect of Erythropoietin on Lymphocytes Apoptosis in Experimental Chronic Renal Failure.

Recombinant human erythropoietin was injected intraperitoneally in a total dose of 900 U/kg to rats with experimental chronic renal failure. Suspension of lymphocytes from animals with chronic renal failure was used in vitro, erythropoietin was used in concentrations of 30, 15, 7.5, 3.

The effects of topical application of metronidazole for treatment of chronic anal fissure: A randomized, controlled pilot study.

Background: Chronic anal fissures (CAFs) rarely heal with conservative management. Because they are associated with strong anal sphincter tone, most treatment aim to reduce anal pressure. Although infections can cause fissures, as can traumatic injury to the anal canal, antimicrobial treatment is not recommended.

Effect of local application of epidermal growth factor on innate immunity and cell composition of destruction focus in experimental thermal injury.

The effect of recombinant human epidermal growth factor (rhEGF) on innate immunity and cellular composition of the destruction focus in the third-degree (IIIA) burn (skin contact with an object heated to 100°C; 4% body surface) was studied in experiments on outbred albino rats. On days 7-28 after burn, blood count of phagocytes and their absorbing capacity and oxygen-dependent metabolism increased, which correlated with the increase in serum IL-1β level and neutrophil count in the destruction focus. Local application of rhEGF led to earlier (on day 14) normalization of the count and functional activity of blood phagocytes and decrease in serum IL-1β level and accelerated neutrophil and lymphocyte replacement with fibroblasts in the focus of injury.