Publications by authors named "L F Stein"
Background: Larsucosterol is a DNA methyltransferase inhibitor in development for alcohol-associated hepatitis (AH), a disease for which there is no approved therapy.
Methods: In this phase 2b trial, patients with severe AH were randomly assigned 1:1:1 to receive 30 mg or 90 mg of larsucosterol or placebo; a second dose was administered after 72 hours if the patient remained hospitalized. All patients received supportive care as determined by investigators.
The Impact of Peer-Based Recovery Support Services: Mediating Factors of Client Outcomes.
J Behav Health Serv Res
January 2025
Research demonstrates a positive impact of Peer Based Recovery Support Services (PBRSS) facilitated by peer recovery specialists (PRS), who are people in recovery from behavioral health conditions (e.g., substance use disorders [SUD] and mental health conditions).
View Article and Find Full Text PDFObjective: To compare the effectiveness of the awake-prone position on relevant clinical outcomes in patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen between different waves in Argentina.
Methods: This multicenter, prospective cohort study included adult patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen. The main exposure position was the awake-prone position (≥ 6 hours/day) compared to the non-prone position.
Article Synopsis
- The study focused on oral health prevention, particularly root caries measures, for patients aged 65 and older, and involved a survey of 365 Norwegian dental hygienists from both public and private sectors.
- Key findings revealed that primary prevention methods included oral hygiene instruction and fluoride varnish, while challenges such as patients' reduced manual dexterity and mobility were particularly noted by public dental hygienists.
- The research highlights the vital role of dental hygienists in promoting oral health for the elderly and underscores various challenges they face in implementing preventive care.
Introduction: Dual-task (DT) exercises combine both physical and cognitive activities and have the potential to efficiently enhance both physical and cognitive function.
Background/objectives: This study aimed to determine if, compared with exercise-only (EO) and control (C) groups, adults in a DT training program improved measures of cognitive and/or physical functioning.
Methods: Thirty-five participants (Mage = 65.