Publications by authors named "L F Stefanelli"
Parietal Epithelial Cells (PECs) activation and proliferation are common to several distinct forms of glomerulopathies. Due to several stimuli, PECs can change to a progenitor (CD24 and CD133/2) or a pro-sclerotic (CD44) phenotype. In addition, PECs, which are constantly exposed to filtered albumin, are known to be involved in albumin internalization, but how this mechanism occurs is unknown.
View Article and Find Full Text PDFPeritoneal catheter dysfunction is one of the most frequent complications of peritoneal dialysis. The malposition of a peritoneal catheter may cause one- or two-way obstruction with fluid outflow or inflow problems, large residual volumes, and, therefore, reduced ultrafiltration and sometimes abdominal pain. Standard procedures may often fail to solve the dysfunction.
View Article and Find Full Text PDFArticle Synopsis
- Bartter's and Gitelman's syndromes are genetic kidney disorders that disrupt electrolyte balance and can lead to serious cardiovascular issues, despite being seen as benign.
- Major heart-related problems can arise, such as arrhythmias, palpitations, and even sudden cardiac death, influenced by chronic electrolyte imbalances and neurohormonal changes.
- The review emphasizes the need for collaboration between nephrologists and cardiologists in managing these patients due to the complex cardiovascular risks associated with these syndromes.