[Rapid methods for evaluation of hygienic standards of drugs in the air at the workplace].

System of calculating methods for staged prognostication of toxicometric parameters and hygienic standards of synthetic drugs was elaborated. This system gives possibility to substantiate quantitative criteria for determination of capacity and directions of investigations in pharmaceutical industry.

[The testing of the carcinogenicity of dispirotripiperazine derivatives by combined administration with sodium nitrite].

The cancerogenic activity of the dispirotripiperasinium derivatives prospidine and spirobromine was tested in concurrent use with sodium nitrite. The drugs were intragastrically administered once a week. It was combined with sodium nitrite, 35 mg/kg, to non-inbred rats of both sex during 24 months.

[The carcinogenic activity of spirobromine].

The carcinogenic activity of spyrobromin was studied during the chronic experiment on 1.5-2-month-old rats and mice of both sexes. The drug was administered intragastrically and intraperitoneally once a week in the maximally tolerant dose for 24 months.

[The hematotoxic and nephrotoxic actions of dispirotripiperazine derivatives in a chronic experiment].

The effects of dispirotripiperazine derivatives spirobromin and prospidin on the parameters of the peripheral blood and behavioral reactions in a chronic 12-month experiment were studied. The experiment was performed on noninbred rats of both sexes. The maximal tolerated doses of the drugs were administered by two routes (intragastrically or intraperitoneally).

[Methodological approaches to evaluating the sensitizing properties of new drug preparations in preclinical trials].

For testing allergenic activity of 18 drugs with various pharmacological properties the reaction of specific leukocyte agglomeration, specific leukocyte lysis reaction, determination of Mg2+ blood serum content and epicutaneous drug application were used. An attempt was made to establish the relationship between the development of immunological response and the time and duration of allergization, the dosage and routes of allergen administration and also to determine the optimal experimental conditions for appearance of the most pronounced response.