[Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan].

Unlabelled: Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific.

Psoriasis patients demonstrate HLA-Cw*06:02 allele dosage-dependent T cell proliferation when treated with hair follicle-derived keratin 17 protein.

It is broadly accepted that psoriasis is an immune-mediated disease with a heritable component, but it is not clear what causes inflammation in the skin. Previous research suggests that fragments of the keratin 17 (K17) protein, which are constitutively expressed in hair follicles, could act as autoantigens. In this study, we synthesized the K17 protein from mRNA derived from hair follicles and tested whether it elicited T cell responses depending on the patient genotype at the major susceptibility locus HLA-Cw*06:02.

[Association of variable rs1801282 locus of PPARG2 gene with diabetic nephropathy].

The association of the variable rs1801282 locus of the PPARG2 gene (peroxisome proliferator-activated receptor gamma) with type 2 diabetes mellitus and its complications was analyzed in inhabitants of the Republic of Bashkortostan. The genotype frequencies of the variable rs1801282 locus of the PPARG2 gene did not significantly differ in groups of healthy persons and patients with type 2 diabetes in all three considered inheritance models (codominant, dominant, and recessive). At the same time, it was demonstrated that the risk of one of the diabetic complications, i.

[Efficiency of hydroxyethyl starch use for arterial hypotension and shock in early postoperative period].

Unlabelled: It is common knowledge that arterial hypotension is a one of most prevalent pathology of early neonatal period and it causes severe neurological complications. Purpose of the prospective randomized open study was to assess the efficacy of HES 130/0.4 (6% Voluven) as a start medicine for arterial hypotension in early neonatal period in comparison with normal saline solution (0.

The central nucleus of the amygdaloid body of the brain: cytoarchitectonics, neuronal organization, connections.

This review considers the questions of the structural-functional organization of the central nucleus (CN) of the amygdaloid body (AB) of the brain in relation to new data on its involvement in the formation of stress reactions and adaptive behavior in animals. Data are presented on the distribution of neuropeptides, neurotransmitters, and modulators in the CN. It is noted that the CN, appearing at the earliest stages of establishment of the AB, is reorganized with it and reflects the evolution of the whole AB.