Publications by authors named "L F Salas"
Objective: This cross-sectional study examined depression and associated impairment in youth presenting to a pediatric emergency department (PED) with abdominal pain.
Methods: Participants were 11-17 years old, presenting to a PED with idiopathic abdominal pain. Participants completed demographics, pain, pain-related impairment, and depression surveys.
We describe Timogenes pipanaco sp. nov. (Scorpiones, Bothriuridae) from north western Argentina.
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- Triple-negative breast cancer (TNBC) is a highly aggressive subtype with varied characteristics, limited treatment choices, and poor clinical outcomes, particularly when associated with homologous recombination deficiency (HRD).
- The study analyzed TNBC tumors from two groups (n=32 and n=58), revealing significant differences in genome-wide copy number and methylation alterations linked to HRD, including lower methylation in specific genomic regions.
- Findings indicate that HRD in TNBC is associated with key biological pathways, and using machine learning can aid in classifying tumors based on HRD and methylation patterns, offering potential for improved treatment strategies.
Over the past century, human lifespan has increased remarkably, yet the inevitability of aging persists. The disparity between biological age, which reflects pathological deterioration and disease, and chronological age, indicative of normal aging, has driven prior research focused on identifying mechanisms that could inform interventions to reverse excessive age-related deterioration and reduce morbidity and mortality. DNA methylation has emerged as an important predictor of age, leading to the development of epigenetic clocks that quantify the extent of pathological deterioration beyond what is typically expected for a given age.
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- This study explores blood biomarkers that can predict responses to immune checkpoint inhibitors (ICIs) for patients with recurrent/metastatic head and neck squamous cell carcinoma, addressing challenges like tumor sample variability.
- Researchers enrolled 100 patients and analyzed blood immune profiles, focusing on factors like tumor mutational burden (TMB) and PD-L1 scores, with a goal to find associations with treatment outcomes.
- Key findings revealed that high levels of neutrophils and monocytes were linked to worse survival, while higher CD4T cells correlated with better outcomes, highlighting the potential of using blood tests for predicting ICI treatment responses.