Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.

Physiological aging is a complex process, influenced by a plethora of genetic and environmental factors. While being far from fully understood, a number of common aging hallmarks have been elucidated in recent years. Among these, transcriptomic alterations are hypothesized to represent a crucial early manifestation of aging.

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.

[Reaction of cells to hypertonic effects by cryoprotection].

Kinetics of volume changes in cells caused by hypertonic solutions has been investigated theoretically using an apparatus of the non-equilibrium thermodynamics. Analytical expressions for relaxation times of the two-stage process studied have been found. The reaction of mouse peritoneal exudate cells to hypertonic solutions of glycerol.