Publications by authors named "L F Plassa"
Background: Skin squamous-cell-carcinoma (SCC), is the main complication in long-term kidney-transplant recipients, and it can include donor-derived cells. Preclinical models demonstrated the involvement of epithelial mesenchymal transition (EMT) in the progression of skin SCC, and the role of Snail, an EMT transcription factor, in cancer stem-cell survival and expansion.Here, we studied stem-cells and EMT expression in SCCs and concomitant actinic keratoses (AK) in kidney-transplant recipients.
View Article and Find Full Text PDFRenal Cell Carcinomas (RCCs) are heterogeneous tumors with late acquisition of TP53 abnormalities during their evolution. They harbor TP53 abnormalities in their metastases. We aimed to study TP53 gene alterations in tissue samples from primary and metastatic RCCs in 36 patients followed up over a median of 4.
View Article and Find Full Text PDFDespite an obvious central role of p53 in the hallmarks of cancer, TP53 status is not yet used for the management of breast cancer. Recent findings may lead to reconsider the role of p53 in breast cancer. TP53 mutations are the most frequent genetic alterations in breast cancer, observed in 30% of breast carcinomas.
View Article and Find Full Text PDFArticle Synopsis
- A study analyzed skin squamous cell carcinoma (SCC) in kidney transplant recipients, focusing on the origin of tumor cells and mutations in the p53 gene.
- Researchers found that in one patient, skin tumor cells had a donor genotype and a specific TP53 mutation, indicating a donor contribution to skin cancer.
- These results highlight the potential risks of cancer development due to prolonged immunosuppression in kidney transplant patients and emphasize the need for careful monitoring.