Publications by authors named "L F Pittet"
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to vaccines against SARS-CoV-2.
Methods: Blood samples, from a subset of 275 SARS-CoV-2-naïve healthcare workers randomised to BCG vaccination (BCG group) or no BCG vaccination (Control group) in the BRACE trial, were collected before and 28 days after the primary course (two doses) of ChAdOx1-S (Oxford-AstraZeneca) or BNT162b2 (Pfizer-BioNTech) vaccination.
Background: The gold standard for diagnosis of meningitis is the isolation of a pathogen from cerebrospinal fluid (CSF) by culture or PCR. However, treatment is routinely commenced based on CSF findings prior to microbiological results. This study determined the predictive value of CSF parameters for diagnosing bacterial and viral meningitis in young infants.
View Article and Find Full Text PDFBackground: Some individuals have a persistence of symptoms following both COVID-19 (post-acute COVID-19 syndrome; PACS) and other viral infections. This study used prospectively collected data from an international trial to compare symptoms following COVID-19 and non-COVID-19 respiratory illness, to identify factors associated with the risk of PACS, and to explore symptom patterns before and after COVID-19 and non-COVID-19 respiratory illnesses.
Methods: Data from a multicentre randomised controlled trial (BRACE trial) involving healthcare workers across four countries were analysed.
Article Synopsis
- Antibiotic therapy for group A streptococcus (GAS) pharyngitis is questioned, mainly for its limited benefits in reducing symptoms rather than preventing complications.
- A study involved 88 children randomly assigned to receive either a placebo or amoxicillin, with results showing that the duration of fever was similar between both groups, indicating that placebo was not inferior to antibiotics.
- The findings suggest that prescribing antibiotics for GAS pharyngitis may not be necessary, as there were no significant differences in pain intensity or complications between the treatment modalities.
Objectives: Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to determine whether BCG vaccination protects adults against COVID-19.
Design: Phase III double-blind randomised controlled trial.