Publications by authors named "L F Pieri"
Background/objectives: Many lasers applied in skin rejuvenation protocols show emissions with wavelengths falling in the red or near-infrared (NIR) bands. To obtain further in vitro data on the potential therapeutic benefits regarding rejuvenation, we employed a 675 nm laser wavelength on cultured human dermal fibroblasts to understand the mechanisms involved in the skin rejuvenation process's signaling pathways by analyzing cytoskeletal proteins, extracellular matrix (ECM) components, and membrane integrins.
Methods: Normal human dermal fibroblasts (NHDFs) were irradiated with a 675 nm laser 24 h after seeding, and immunofluorescence microscopy and Western blotting were applied.
Article Synopsis
- Plastics, especially microplastics and nanoplastics, pose serious environmental and health risks due to their durability and ability to interact with living organisms.
- Recent research explored how human α-synuclein (hαSn) interacts with polyethylene-based nanoplastics using molecular dynamics and experiments, revealing significant structural changes in hαSn upon exposure.
- Findings indicate that non-oxidized polyethylene nanoplastics effectively bind hαSn and alter its structure, while oxidized variants do not, highlighting potential health implications of these NP-protein interactions.
: Urinary incontinence (UI) is the involuntary loss of urine caused by a weakness in the pelvic floor muscles (PFMs) that affects urethral closure. Myostatin, which prevents the growth of muscles, is a protein expressed by human skeletal muscle cells. Indeed, it has been observed that myostatin concentration rises during skeletal muscle inactivity and that suppressing serum myostatin promotes muscle growth and strength.
View Article and Find Full Text PDFSingle-stranded, positive-sense RNA ((+)RNA) viruses replicate their genomes in virus-induced intracellular membrane compartments. (+)RNA viruses dedicate a significant part of their small genomes (a few thousands to a few tens of thousands of bases) to the generation of these compartments by encoding membrane-interacting proteins and/or protein domains. Noroviruses are a very diverse genus of (+)RNA viruses including human and animal pathogens.
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- * In vitro tests showed that the laser stimulates cell proliferation, while clinical trials involved 39 patients, resulting in high satisfaction scores and significant improvements in skin conditions.
- * The findings indicate that the 675-nm laser is both effective and safe, with treatment times reduced by 50%, making it a promising option for dermatological therapies.