The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats.

Childhood obesity increases the risk of developing metabolic diseases in adulthood, since environmental stimuli during critical windows of development can impact on adult metabolic health. Studies demonstrating the effect of prepubertal diet on adult metabolic disease risk are still limited. We hypothesized that a prepubertal control diet (CD) protects the adult metabolic phenotype from diet-induced obesity (DIO), while a high-fat diet (HFD) would predispose to adult metabolic alterations.

Echinacoside promotes collagen synthesis and survival via activation of IGF-1 signaling to alleviate UVB-induced dermal fibroblast photoaging.

Ultraviolet (UV) irradiation is a major factor contributing to skin photoaging, including the formation of reactive oxygen species (ROS), collagen breakdown, and overall skin damage. Insulin-like growth factor-I (IGF-1) is a polypeptide hormone that regulates dermal survival and collagen synthesis. Echinacoside (Ech), a natural phenylethanoid glycoside, is the most abundant active compound in Cistanches.

Dextran produced by native strains isolated of Agave salmiana inhibits prostate and colon cancer cell growth.

Biomaterials such as exopolysaccharides have been of great interest for their diverse biological activities in controlling or preventing chronic degenerative diseases, such as cancer. Previously, we isolated four dextrans produced by four strains isolated from Agave salmiana, which were named SF3, SF2, SD1, and SD23. The objective was to evaluate the antitumor activity of these dextrans on prostate (PC3) and colon (SW480) cancer cells.

CHO Isomers: Insights into Potential Interstellar Species.

2-Methoxyethanol, with a formula CHO was recently identified in the massive protocluster NGC 6334I. However, its structural isomers, 1,2-propanediol and 1,3-propanediol, remain undetected despite extensive searches in the Sgr B2 region. In this study, we explored the potential energy surface of the CHO system using CCSD(T)/aug-cc-pVTZ//MP2/aug-cc-pVTZ calculations, identifying 11 species, with the geminal diols 2,2-propanediol and 1,1-propanediol as the most stable forms.